The Anemia of Scurvy
نویسندگان
چکیده
1. Weight loss, progressive anemia, and a moderate increase in reticulated red blood cells occurred in seventeen guinea pigs on a diet deficient in vitamin C. 2. The histological changes of the bone marrow removed from guinea pigs with scurvy showed large numbers of erythrogenic cells, but scant evidence of active maturation to the adult erythrocyte. 3. A reticulocyte response was induced in guinea pigs with scurvy when fed orange juice daily. 4. The histological changes of the bone marrow removed from guinea pigs during the reticulocyte response showed large numbers of mitotic figures and relatively more adult red blood cells than in the bone marrow from guinea pigs with scurvy that had not been treated with orange juice. 5. It is concluded from this study that the anemia of experimentally induced scurvy in the guinea pig is largely dependent upon vitamin C deficiency resulting in retarded maturation of the red blood cell.
منابع مشابه
Experimental nutritional megaloblastic anemia and scurvy in the monkey. III. Protoporphyrin, coproporphyrin, urobilinogen and iron in blood and excreta.
متن کامل
Experimental megaloblastic anemia and scurvy in the monkey. V. Nature of the relation of ascorbic acid deficiency to the metabolism of folic acid compounds.
was a regular complications of scurvy ins monkeys fed milk diets. Reports have beers published concerning the various manifestations in the animals’ arid of the hematologic findings.2 This paper provides data on the vitamin Bn2 and folic acid compounds ins the liver, diets arid excreta of the experimental ansimals. These data are correlated with the findings iii the horse marrow and the effects...
متن کاملExperimental megaloblastic anemia and scurvy in the monkey. IV. Vitamin B12 and folic acid compounds in the diet, liver, urine and feces and effects of therapy.
was a regular complications of scurvy ins monkeys fed milk diets. Reports have beers published concerning the various manifestations in the animals’ arid of the hematologic findings.2 This paper provides data on the vitamin Bn2 and folic acid compounds ins the liver, diets arid excreta of the experimental ansimals. These data are correlated with the findings iii the horse marrow and the effects...
متن کاملMegaloblastic anaemia associated with adult scurvy.
Nowadays scurvy is fortunately rare. Cases are still found among the inmates of common lodging houses and those living alone, where age, decrepitude, or apathy may have led to an inadequate dietary intake. Rigid dieting as in peptic ulcer' may be an unusual cause. While the blood picture may show little change in the milder cases, anaemia of variable degree occurs in most adults with scurvy. It...
متن کاملScurvy: an unusual cause of anemia.
Nutritional deficiencies are a common cause of anemia. We describe a case of a schizophrenic patient with a rapidly declining hematocrit. The patient was a long-term inpatient at a psychiatric hospital. He was brought to the emergency department with acute anemia initially thought to be secondary to gastrointestinal bleeding. Other causes for his anemia were investigated when gastrointestinal b...
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عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 55 شماره
صفحات -
تاریخ انتشار 2003